Research
The Pouget Lab is a computational (dry) lab that leverages large-scale human genetic studies and multiomic sequencing technologies to understand how the brain works at a molecular level. We use these insights to shed light on the neurobiology of psychosis and related disorders. The ultimate goal of our research is to translate molecular discoveries into earlier, more personalized interventions and prevention strategies for young people experiencing mental illness.
Highlighted
Fine-mapping the CYP2A6 regional association with nicotine metabolism among African American smokers.
Molecular psychiatry
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31 Aug 2024
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pubmed:39217253
Cross-disorder analysis of schizophrenia and 19 immune-mediated diseases identifies shared genetic risk.
Human molecular genetics
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15 Oct 2019
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pubmed:31211845
A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases.
Nature genetics
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16 May 2016
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pubmed:27182969
All
2025
Molecular Signatures of Early-Onset Bipolar Disorder and Schizophrenia: Transcriptomic and Machine-Learning Insights into Calcium and cAMP Signaling, Including Sex-Specific Patterns.
International journal of molecular sciences
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16 Dec 2025
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pubmed:41465535
2024
Association between maternal schizophrenia and risk of serious asthma exacerbations in childhood.
Schizophrenia research
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20 Dec 2024
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pubmed:39708390
Sex-dependent association study of complement C4 gene with treatment-resistant schizophrenia and hospitalization frequency.
Psychiatry research
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23 Sep 2024
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pubmed:39342786
Fine-mapping the CYP2A6 regional association with nicotine metabolism among African American smokers.
Molecular psychiatry
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31 Aug 2024
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pubmed:39217253
Association study of the complement component C4 gene and suicide risk in schizophrenia.
Schizophrenia (Heidelberg, Germany)
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10 Feb 2024
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pubmed:38341430
CYP2A6 associates with respiratory disease risk and younger age of diagnosis: a phenome-wide association Mendelian Randomization study.
Human molecular genetics
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07 Jan 2024
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pubmed:37802914
2023
Associating CYP2A6 structural variants with ovarian and lung cancer risk in the UK Biobank: replication and extension.
European journal of human genetics : EJHG
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14 Dec 2023
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pubmed:38097766
Heart rate variability: Evaluating a potential biomarker of anxiety disorders.
Psychophysiology
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21 Nov 2023
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pubmed:37990619
Genotyping, characterization, and imputation of known and novel CYP2A6 structural variants using SNP array data.
Journal of human genetics
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14 Apr 2023
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pubmed:37059825
2022
Exploring the association of interleukin polymorphisms with aggression and internalizing behaviors in children and adolescents.
Brain and behavior
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28 Sep 2022
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pubmed:36168941
Pharmacogenetics of Antipsychotic Treatment in Schizophrenia.
Methods in molecular biology (Clifton, N.J.)
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01 Jan 2022
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pubmed:36068471
2021
Transferability of Ancestry-Specific and Cross-Ancestry CYP2A6 Activity Genetic Risk Scores in African and European Populations.
Clinical pharmacology and therapeutics
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01 Jan 2021
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pubmed:33300144
2019
Association Study of the Complement Component C4 Gene in Tardive Dyskinesia.
Frontiers in pharmacology
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26 Nov 2019
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pubmed:31849639
Cross-disorder analysis of schizophrenia and 19 immune-mediated diseases identifies shared genetic risk.
Human molecular genetics
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15 Oct 2019
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pubmed:31211845
The complement system in schizophrenia: where are we now and what's next?
Molecular psychiatry
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22 Aug 2019
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pubmed:31439935
2018
The Emerging Immunogenetic Architecture of Schizophrenia.
Schizophrenia bulletin
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20 Aug 2018
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pubmed:29701842
A Comprehensive Analysis of Nuclear-Encoded Mitochondrial Genes in Schizophrenia.
Biological psychiatry
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15 Mar 2018
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pubmed:29628042
2017
Joint evaluation of serum C-Reactive Protein levels and polygenic risk scores as risk factors for schizophrenia.
Psychiatry research
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21 Dec 2017
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pubmed:29306175
Genetic risk scores and family history as predictors of schizophrenia in Nordic registers.
Psychological medicine
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25 Sep 2017
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pubmed:28942743
2016
Impact of histamine receptors H1 and H3 polymorphisms on antipsychotic-induced weight gain.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
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15 Dec 2016
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pubmed:27855565
Rapporteur summaries of plenary, symposia, and oral sessions from the XXIIIrd World Congress of Psychiatric Genetics Meeting in Toronto, Canada, 16-20 October 2015.
Psychiatric genetics
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01 Dec 2016
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pubmed:27606929
Genomics implicates adaptive and innate immunity in Alzheimer's and Parkinson's diseases.
Annals of clinical and translational neurology
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04 Nov 2016
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pubmed:28097204
Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study.
PLoS medicine
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21 Jun 2016
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pubmed:27327646
Genome-Wide Association Studies Suggest Limited Immune Gene Enrichment in Schizophrenia Compared to 5 Autoimmune Diseases.
Schizophrenia bulletin
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30 May 2016
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pubmed:27242348
A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases.
Nature genetics
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16 May 2016
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pubmed:27182969
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
Nature genetics
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14 Mar 2016
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pubmed:26974007
Cerebrovascular and microglial states are not altered by functional neuroinflammatory gene variant.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
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13 Jan 2016
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pubmed:26762507
2015
Increased Nigral SLC6A3 Activity in Schizophrenia Patients: Findings From the Toronto-McLean Cohorts.
Schizophrenia bulletin
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26 Dec 2015
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pubmed:26707863
Investigation of TSPO variants in schizophrenia and antipsychotic treatment outcomes.
Pharmacogenomics
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01 Jan 2015
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pubmed:25560467
2014
Pharmacogenetics and outcome with antipsychotic drugs.
Dialogues in clinical neuroscience
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01 Dec 2014
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pubmed:25733959
The three-year incidence of fracture in chronic kidney disease.
Kidney international
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15 Jan 2014
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pubmed:24429401
Pharmacogenetics of antipsychotic treatment in schizophrenia.
Methods in molecular biology (Clifton, N.J.)
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01 Jan 2014
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pubmed:25150876
2013
Characterization of bla(SHV) genes on plasmids from Escherichia coli and Salmonella enterica isolates from Canadian food animals (2006-2007).
Applied and environmental microbiology
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05 Apr 2013
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pubmed:23563948
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